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zyrtec
CetirizineSystematic (IUPAC) name(±) - -1- piperazinyl] ethoxy]acetic acid, dihydrochlorideIdentifiersCAS number83881-51-0ATC codeR06AE07PubChem2678DrugBankAPRD00630ChemSpider2577Chemical dataFormulaC21H25ClN2O3 Mol. mass388.89SMILESeMolecules & PubChemSynonymsAlatrol, Alzene, Cetirizina MERCK, Cetirin, Cetzine Glaxo, Cetirizin, Humex, Letizen, Razene, Reactine, Zyrtec, Zirtec, Zodac, Zirtek, Zynor, Zyrlek, ZyllergyPharmacokinetic dataBioavailabilitywell absorbedProtein binding93% avgMetabolismCYP3A4 (Cytochrome P450 3A4)Half life8.3 HoursExcretionHepatic, urine or excrement (Small amounts)Therapeutic considerationsLicence dataUSPregnancy cat.B(US)Legal statusGSL(UK) OTC(US) OTC in CanadaRoutesOralCetirizine hydrochloride (pronounced /sɛˈtɪrɨziːn/), an antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. The structural similarity of cetirizine to hydroxyzine, and its derivation from piperazine, attribute similar adverse reactions and properties to other piperazine derivatives.Formerly prescription-only in the US and Canada, cetirizine is now available over the counter in both. In the UK cetirizine can be sold in any outlet and is often available in supermarkets.// PharmacologyCetirizine crosses the blood-brain barrier only slightly, eliminating the sedative side-effect common with older antihistamines; however it still causes mild drowsiness. Administration method and metabolisationChewable, non-chewable, and syrup forms of cetirizine are similarly absorbed rapidly and effectively, with absorbed food minutely affecting the absorption rate which yields a peak serum level one hour after administration; in a study of healthy volunteers prescribed 10mg tablets, once daily for 10 days, a mean peak serum level of 311 ng/mL was observed. The metabolic effects of cetirizine are long acting; remaining in the system for a maximum of 21 hours before being excreted, the average elimination half-life is 8 hours. 70% of the drug is excreted or eliminated by kidney function within 72 hours, and 10% is removed through urine or excrement; of which half is observed as unchanged cetirizine compound. Like many other antihistamine medications, cetirizine is commonly prescribed in combination with pseudoephedrine hydrochloride, a decongestant. These combinations are marketed using the same brand name as the cetirizine with a "-D" suffix (Zyrtec-D, Virlix-D, etc.)Additionally, cetirizine HCl not sold in combination with pseudoephedrine, is commonly known and marketed in the United States under the brand name, "Zyrtec." Formerly only available by a prescription, both Zyrtec and Zyrtec-D are currently available over the counter in the United States. In the Philippines, a leading cetirizine is Aforvir. Levorotary isomerThe levorotary enantiomer of cetirizine is known as levocetirizine. It is marketed under the name of Xyzal and Xusal. It is claimed to have somewhat fewer side effects. Kimura's diseaseCetirizine is an effective agent in the treatment of Kimura's disease, which mostly occurs in young Asian men, affecting the lymph nodes and soft tissue of the head and neck in the form of tumor-like lesions. Cetirizine's properties of being effective both in the treatment of pruritus and as an anti-inflammatory agent make it suitable for the treatment of the pruritus associated with these lesions. In a 2005 study, the American College of Rheumatology conducted treatments initially using prednisone, followed by steroid dosages and azathioprine, omeprazole, and calcium and vitamin D supplements over the course of two years. The skin condition of the patient began to improve and the skin lesions lessened. However, there were symptoms of cushingoid and hirsutism observed before the patient was removed from the courses of steroids and placed on 10mg/day of cetirizine to prevent skin lesions;an agent suitable for the treatment of pruritus associated with such lesions. Asymptomatically, the patient's skin lesions disappeared after treatment with cetirizine, blood eosinophil counts became normal, corticosteroid effects were resolved, and a remission began within a period 2 months. It is also thought that the inhibition of eosinophils may be the key to treatment of Kimura's disease due to the role of eosinophils, rather than other cells with regards to the lesions of the skin.
exclusivity of Zyrtec, which Pfizer ceased selling.Stumbling around the Net today, I found a blog post by someone doing resarch on Zyrtech, an anti-histamine made by Pfizer. Some Wall Street analysts were pretty glum about the companyâs first-quarter earnings announcement. Last seen: while waiting for Claritin to start working.8 billion, a decrease of 5% compared with $12.Pharmaceutical and biotechnology major Wockhardt announced the launch of Cetirizine tablets in the USA.Pfizer Inc (NYSE: PFE) reported results for the first-quarter 2008.. Zyrtec is used to treat allergies, hives (urticaria), and other allergic inflammatory conditions..(more)Buy Zyrtec at TrustStorePills.Profit fell 18%, cholesterol drug Lipitor saw another decline despite competing Vytorinâs woes, and sales of allergy drug Zyrtec and Is this really the best that Pfizer can do? How can you really advertise a drug like this? It has to be against some law.FDA warning to healthcare professionals according to an alert from MedWatch.. Zyrtec is an antihistamine. Prescription bottles bearing catchy brand names are being pushed aside by tongue-twisting generics.com - Only the best pills from the trusted online pharmacy store.. It treats the symptoms, so you can enjoy the time you spend with your family. The gist of
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zyrtec
Zyrtec (cetirizine) is used to treat allergy symptoms such as sneezing, itching, watery eyes, or runny nose. Includes Zyrtec side effects, interactions and indications.
Zyrtec Information from Drugs.com
ZYRTEC allergy medication, now available in prescription strength, but as over the counter provides relief from indoor and outdoor upper respiratory allergies for adults and ...
Allergy Relief Medicine, Allergy Symptom Treatment - ZYRTEC.com
Zyrtec. CenterWatch Clinical Pharmacology: Cetirizine, a medication prescribed to respond to Take Online. The repercussions of the active ingredient Cetirizine or perennial ...
ZYRTEC • • •
These combinations are marketed using the same brand name as the cetirizine with a "-D" suffix (Zyrtec-D, Virlix-D, etc.) Levo version. The levo, or active enantiomer, version of ...
Cetirizine - Wikipedia, the free encyclopedia
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