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protonix
PantoprazoleSystematic (IUPAC) name6-(difluoromethoxy)-2--1H-benzoimidazoleIdentifiersCAS number102625-70-7ATC codeA02BC02PubChem4679DrugBankAPRD00073ChemSpider4517Chemical dataFormulaC16H15F2N3O4S Mol. mass383.371 g/molSMILESeMolecules & PubChemPharmacokinetic dataBioavailability77%MetabolismHepatic (CYP2C19 and 3A4)Half life1 hourExcretionRenalTherapeutic considerationsLicence dataUS FDA:linkPregnancy cat.B3(AU) B(US)Legal status℞ Prescription onlyRoutesOral and intravenousPantoprazole (Sold as Pantotab; Pantopan; Protium; Protonix; Pantozol; Pantor; Pantoloc; Astropan; Controloc; Pantecta; Inipomp; Ulcepraz) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained. This medication may affect the results of certain lab tests, such as drug screenings (pantoprazole can cause a false positive for THC). It is recommended you make sure laboratory personnel and your doctor know you are using this drug. The active ingredient in PROTONIX (pantoprazole sodium) Delayed-Release Tablets is a substituted benzimidazole , sodium 5-(difluoromethoxy)-2- sulfinyl]-1 H -benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion.// PharmacologyPantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance. Pantoprazole is relatively free of drug interactions, however it may alter the absorption of other medications that depend on the amount of acid in the stomach, such as ketoconazole or digoxin. AvailabilityPantoprazole was developed by Altana and is currently marketed under the brand name Protonix by Wyeth-Ayerst Laboratories, Somac by Pfizer, Astropan by Astron Lifesciences , Pantor by Bosnalijek, and as Pantoloc or Somac by Nycomed, as Protium in the UK, as Inipomp in France, as Pantozol by Nycomed in Germany, Propozol in India, Zurcazol in Greece, and as TopZole in South Africa. It is manufactured by a joint venture company Zydus Altana Private Limited which was formed by Altana and Cadila Healthcare. The plant is located at Thane, Maharashtra 421305, India. It is available by prescription in delayed-release tablets. It is also available for intravenous use.On December 24, 2007, Teva Pharmaceutical released an AB-rated generic alternative to Protonix. A study published in the August 12, 2008 issue of the Canadian Medical Association Journal found that those who use proton pump inhibitors for five or more years have a 1.6-fold increased risk of fracturing a hip, while those who use the drugs for 7 or more years have a 4.5 fold increased risk of fracturing a hip.
Acid reflux and Apple Cider Vinegar, Apples, Burping, Caffeine, Baking Soda, Beer, Honey, Lump in the throat, Throat Clearing, Protonix.Drug maker Wyeth revealed that it has received additional subpoenas from a Massachusetts grand jury, over a pricing scandal involving its heartburn drug, Protonix.Protonix10 Tips on dealing with heartburn and acid reflux..Euflexxa Lipitor Actonel Fosamax Effexor Protonix Plavix Celebrex Flomax Nexium Synvisc Prevacid Evista Juvederm Orthovisc Restylane Zyprexa HyalganEuflexxa Lipitor Actonel Fosamax Effexor Protonix Plavix Celebrex Flomax Nexium Synvisc Prevacid Evista Juvederm Orthovisc Restylane Zyprexa HyalganThat news comes from a Canadian study of proton pump inhibitors (PPIs) and osteoporosis-related fractures. PPIs are a class of drugs that include Aciphex, Nexium, Prevacid, Prilosec, and ProtonixThe study shows a link between long-term use of proton pump inhibitors and greater likelihood of osteoporosis-related
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Manage erosive acid reflux, treat associated symptoms of acid reflux, and heal esophageal erosions. Learn more.
PROTONIX.com: Managing Acid Reflux Disease with PROTONIX
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Learn about the prescription medication Protonix Tablets (Pantoprazole), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.
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