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PhentermineSystematic (IUPAC) name2-methyl-1-phenylpropan-2-amine and 2-methyl-amphetamineIdentifiersCAS number122-09-8ATC codeA08AA01 C01CA11PubChem4771DrugBankAPRD00093ChemSpider4607Chemical dataFormulaC10H15N Mol. mass149.233 g/molPharmacokinetic dataBioavailabilityPeak plasma levels occur within 1 to 4.5 hours. Absorption is usually complete by 4 to 6 hoursProtein bindingApproximately 96.3%MetabolismhepaticHalf life16 to 31 hoursExcretionUrinary eliminationTherapeutic considerationsPregnancy cat.C(US)Legal statusSchedule IV(US)RoutesOral, Insufflation, IntravenousPhentermine, a contraction for "phenyl-tertiary-butylamine", is an appetite suppressant of the amphetamine and phenethylamine class.It is approved as an appetite suppressant to help reduce weight in obese patients when used short-term and combined with exercise, diet, and behavioral modification. It is typically prescribed for individuals who are at increased medical risk because of their weight and works by helping to release certain chemicals in the brain that control appetite.// Commercial trade namesAdipex P (Immediate release)Anoxine-AMIonamin (Slow Release Resin, Australia, discontinued in the US)Duromine (Slow Release Resin, New Zealand, Australia & South Africa)FastinMiraprontObephenObermineObestin-30PhentrolPhenterexPhentrominPro-Fast SARedusaPanbesyPhentermine TrenkerObenixOby-TrimTeramineZantrylSinpet (MX)Supremin (PH)Umine (NZ)Weltmine (KP) HistoryIn 1959 phentermine first received approval from the FDA as an appetite suppressing drug. Phentermine hydrochloride then became available in the early 1970s. It was previously sold as Fastin from King Pharmaceuticals for SmithKline Beecham, however in 1998 it was removed from the market. Medeva Pharmaceuticals sells the name brand of phentermine called Ionamin and Gate Pharmaceuticals sells it as Adipex-P. Phentermine is also currently sold as a generic. Since the drug was approved in 1959 there have been almost no clinical studies performed. The most recent study was in 1990 which combined phentermine with fenfluramine or dexfenfluramine and became known as Fen-Phen.In 1997 after 24 cases of heart valve disease in Fen-Phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. Studies later proved that nearly 30% of people taking fenfluramine or dexfenfluramine had abnormal valve findings. The FDA did not ask manufacturers to remove phentermine from the market.Phentermine is still available by itself in most countries, including the U.S. However, because it is similar to amphetamines, it is classified as a controlled substance in many countries. Internationally, phentermine is a schedule IV drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act. Mechanism of actionPhentermine, in doses clinically used, works on the hypothalamus portion of the brain to release norepinephrine, a neurotransmitter or chemical messenger that signals a fight-or-flight response, reducing hunger. Phentermine works outside the brain as well to release epinephrine or adrenaline causing fat cells to break down stored fat, but the principal basis of efficacy is hunger-reduction. At high doses, phentermine releases serotonin and dopamine as well, but such doses are never used in clinical medicine. Dosing and administrationGenerally, it is recommended by the Food and Drug Administration(FDA) that phentermine should be used short-term (usually interpreted as 'up to 12 weeks'), while following nonpharmacological approaches to weight loss such as healthy dieting and exercise. Contraindications and warningsPatients with the following should not use Phentermine:An allergy to any ingredient in Phentermine or other sympathomimetics (eg, pseudoephedrine)Are also taking dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the last 14 daysHave severe high blood pressure, an overactive thyroid, glaucoma, heart or blood vessel disease, or severe narrowing of the blood vesselsAre in an agitated state, or have a history of substance abuseSome medical conditions may interact with Phentermine, patients with the following should consult with their doctor before using phentermine:Are pregnant, planning to become pregnant, or are breast-feedingAre taking any prescription or nonprescription medicine, herbal preparation, or dietary supplementHave allergies to medicines, foods, or other substancesHave a brain or spinal cord disorder, hardening of the arteries, high blood pressure, diabetes, or high cholesterol or lipid levelsSome medicines may interact with phentermine, such as the following:Dexfenfluramine, fenfluramine, furazolidone, or MAOIs (eg, phenelzine) because the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increasedGuanadrel(Hylorel) or guanethidine(Ismelin) because their effectiveness may be decreased by phentermineAntacids: Antacids may decrease the excretion of phentermine. Carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, methazolamide): Carbonic anhydrase inhibitors may decrease the excretion of phentermine. Side effectsGenerally, phentermine appears to be relatively well tolerated. It can produce side effects consistent with its catecholamine-releasing properties, e.g., tachycardia (increased heart rate) and elevated blood pressure, but the incidence and magnitude of these appear to be less than with the amphetamines. Because phentermine acts through sympathomimetic pathways, the drug may increase blood pressure and heart rate. It may also cause palpitations, restlessness, and insomnia. Additionally, phentermine has the potential to cause physical and psychological dependence. More commonInsomniaHypertensionIrritabilityNervousnessEuphoriaDry mouthUnpleasant tasteBlurred visionHeartburn/Acid refluxChanges in libidoClumsinessConfusionDiarrheaDizzinessHeadacheArrhythmiaNausea or vomitingPsychosisSkin rash or itchingStomach painFatigue Less commonConvulsions (seizures)DizzinessFeverHallucinationsHostility with urge to attackIrregular blood pressureLightheadedness or faintingPeriods of mania followed by period of depressionTremors, trembling or shakingOveractive reflexesPanicRestlessnessSevere nausea, vomiting or diarrheaStomach crampsWeakness

It helps people lose weight and can only be used for short term in combination with physical exercises and special diet..Where can I get phentermine without a prescription? Hi Can you all please give me advise or some sites that I can ordery phentermine on without a prescription.Many dieters made their dream come true and dropped a few pounds with the help of this appetite suppressant. Phendimetrazine works by stimulating the central nervous system, which increases your heart rate and blood pressure and decreases your appetite. The link is trying to sell Viagra, phentermine (sic) among other drugs.buy cheap medicine,buy cheap prescription drugs,buy cheap prescriptions,cheap generic prescription drugs,cheap generic ,rescriptions,generic lavitra,generic uprima,get sildenafil,herbal sildenafil,pharmacy sildenafil,phentermine generics,silagra online,sildenafil citrate soft tab,sildenafil cost,sildenafil medication,sildenafil on line,sildenafil oProvided you are not satisfied with your Body Mass Index which shows you can be qualified as overweight or obese, you might be thinking about choosing the weight loss pills. It tells how Phentermine works inside your body and reduces you weight and also it gives several reasons why people should not take Phentermine.. Adipex is stimulant that affects the central nervous system, namely certain parts of it, which are responsible for the feeling of hunger.Phentermine

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