norvasc
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norvasc
AmlodipineSystematic (IUPAC) name3-ethyl 5-methyl 2--4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylateIdentifiersCAS number88150-42-9ATC codeC08CA01PubChem2162DrugBankAPRD00520ChemSpider2077Chemical dataFormulaC20H25ClN2O5 Mol. mass408.879 g/molSMILESeMolecules & PubChemPharmacokinetic dataBioavailability64 to 90%MetabolismHepaticHalf life30 to 50 hoursExcretionRenalTherapeutic considerationsPregnancy cat.C(AU) C(US)Legal statusPOM(UK) ℞-only(US)RoutesOral (tablets)Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker (dihydropyridine class) used as an anti-hypertensive and in the treatment of angina. Like other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence reducing blood pressure; in angina it increases blood flow to the heart muscle.Amlodipine is marketed as Dailyvasc in the Philippines by Xeno Pharmaceuticals, and by Pfizer as Norvasc in North America, Australia and some European countries, and as Istin in the United Kingdom. Generic brands (sold under names such as Perivasc in Australia) are also available.// Indicationshypertensionprophylaxis of angina Cautionshepatic impairmentpregnancy Contraindicationscardiogenic shockunstable anginasignificant aortic stenosisbreast feeding Side effectsSome side effects of the use of amlodipine may be:Very often: peripheral edema (feet and ankles) - in 1 of 10 usersOften: dizziness; palpitations; muscle-, stomach- or headache; dyspepsia; nausea - in 1 in 100 usersSometimes: blood disorders, development of breasts in men (gynecomastia), impotence, depression, insomnia, tachycardia - in 1 in 1,000 usersRarely: erratic behavior, hepatitis, jaundice - in 1 in 10,000 usersVery rarely: hyperglycemia, tremor, Stevens-Johnson syndrome - in 1 in 100,000 users DoseHypertension or angina: 5 or 10 mg once daily (initial treatment can start as low a 2.5 mg per day). SaltsIn the United Kingdom tablets of amlodipine from different suppliers may contain different salts. The strength of the tablets is expressed in terms of amlodipine base, i.e., without the salt. Tablets containing different salts are therefore considered interchangeable. Drug metabolism and excretionAmlodipine is almost entirely metabolised to inactive metabolites. Ten per cent of the parent substance and 60% of the metabolites are excreted in urine. Patent lossPfizer patent protection on Norvasc lasted until 2007. A number of generic versions are now available. Total patent expiration occurred later in 2007.
.. Direction for use and dose:- if you suffer from arterial hypertensia or stenocardia you should take 1 mg of Norvasc once a day; you may enlarge the dose up to 10 mg depending of your individual reaction.8 billion, a decrease of 5% compared with $12.Keywords:10 brand mg name norvasc onlinebuy generic norvasc onlinebuy norvasc medication onlineCan prednisone cause hair loss, calcium coral gold, canine effects lasix, car brite mobile detailing, calcium carbonate in acid, calcium carbonate photo, canadian pharmacies norvasc, can prevacid cause sleepinessA real world side effects and drug interactions study of Norvasc (amlodipine besylate). For the fourth-quarter 2007, Pfizer recorded revenues of $13. It can also be employed for other conditions as determined by your doctor.. Generic Norvasc is also employed to treat hypertension and the angina, which is accompanied by the pains of trunk in a patient. The study is based on over 68,000 adverse drug incidents since 1996 from www.6 bn Norvasc mkt (update)Generic Norvasc belongs to a class of the drugs called the adjusters of calcium. The Company recorded revenues of $11. That functions beside slackening (expansion) your blood vessels, lowering the blood pressure, and decreasing. The present part of the site of eMedTV other described
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norvasc
NORVASC treats high blood pressure and the chest pain of angina.
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