norvasc
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norvasc
AmlodipineSystematic (IUPAC) name3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylateIdentifiersCAS number88150-42-9ATC codeC08CA01PubChem2162DrugBankAPRD00520ChemSpider2077Chemical dataFormulaC20H25ClN2O5 Mol. mass408.879 g/molSMILESeMolecules & PubChemPharmacokinetic dataBioavailability64 to 90%MetabolismHepaticHalf life30 to 50 hoursExcretionRenalTherapeutic considerationsPregnancy cat.C(AU) C(US)Legal statusPOM(UK) ℞-only(US)RoutesOral (tablets)Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker (dihydropyridine) used as an anti-hypertensive and in the treatment of angina. Like other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence reducing blood pressure; in angina it increases blood flow to the heart muscle.Amlodipine is marketed as Dailyvasc in the Philippines by Xeno Pharmaceuticals. Norvasc in North America and as Istin in the United Kingdom by Pfizer as well as other generic brands available.// Indicationshypertensionprophylaxis of angina Cautionshepatic impairmentpregnancy Contraindicationscardiogenic shockunstable anginasignificant aortic stenosisbreast feeding Side effectsSome side effects of the use of amlodipine may be:Very often: peripheral oedema (feet and ankles) - in 1 of 10 usersOften: dizziness; palpitations; muscle-, stomach- or headache; dyspepsia; nausea - in 1 in 100 usersSometimes: blood disorders, development of breasts in men (gynecomastia), impotence, depression, insomnia, tachycardia - in 1 in 1,000 usersRarely: erratic behavior, hepatitis, jaundice - in 1 in 10,000 usersVery rarely: hyperglycemia, tremor, Stevens-Johnson syndrome - in 1 in 100,000 users DoseHypertension or angina: 5 or 10 mg once daily (initial treatment can start as low a 2.5 mg per day). SaltsIn the United Kingdom tablets of amlodipine from different suppliers may contain different salts. The strength of the tablets is expressed in terms of amlodipine base, i.e., without the salt. Tablets containing different salts are therefore considered interchangeable. Drug Metabolism and ExcretionAmlodipine is almost entirely metabolised to inactive metabolites. Ten per cent of the parent substance and 60% of the metabolites are excreted in urine. Patent lossPfizer patent protection on Norvasc lasted until 2007. A number of generic versions are now available. Total patent expiration occurred later in 2007.
1 billion, an increase of 4% compared with $12. exclusivity of Norvasc as well as the January 2008 loss of U.. The present part of the site of eMedTV other described potential Norvasc and its uses, effects, and side effects. That functions beside slackening (expansion) your blood vessels, lowering the blood pressure, and decreasing..Norvasc is the shape of adjuster of calcium channel which contributes to the hypotension and types of feast to some of angina..Pfizer Inc (NYSE: PFE) reported results for the fourth-quarter and full-year 2007.6 billion in the year-ago quarter, primarily due to the March 2007 loss of U.. Generic Norvasc is an adjuster of calcium channel.Cialis online pharmacy buy VIAGRA cialis cocaine combination.Wockhardt to enter USD 2. . seroxat buy phentermine buy wellbutrin buy ultram online ascertainment norvasc . Generic Norvasc is also employed to treat hypertension and the angina, which is accompanied by the pains of trunk in a patient..Treatment of hypertension and the angina (pain of trunk).S.... exclusivity of Zyrtec, which Pfizer ceased selling.S.
Even more about norvasc
norvasc
NORVASC treats high blood pressure and the chest pain of angina. ... Proven treatment for high blood pressure. NORVASC ® (amlodipine besylate) is the most prescribed brand name ...
NORVASC ® (amlodipine besylate) - Official Site - Lower High Blood ...
Norvasc (amlodipine) is a calcium channel blocker used to treat high blood pressure and angina. Includes Norvasc side effects, interactions and indications.
Norvasc Information from Drugs.com
NORVASC helps control high blood pressure for a full 24 hours. And it can be used to treat the chest pain of angina.
NORVASC ® (amlodipine besylate) - Official Site - Control High Blood ...
... in the arterial wall, decreasing peripheral resistance and hence reducing blood pressure; in angina it increases blood flow to the heart muscle. Amlodipine is marketed as Norvasc in ...
Amlodipine - Wikipedia, the free encyclopedia
1 Norvasc® (amlodipine besylate) Tablets DESCRIPTION NORVASC® is the besylate salt of amlodipine, a long-acting calcium channel blocker. Amlodipine besylate is chemically ...
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