lopressor
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lopressor
MetoprololSystematic (IUPAC) name{2-hydroxy- 3- propyl} (propan- 2-yl) amineIdentifiersCAS number37350-58-6ATC codeC07AB02PubChem4171DrugBankAPRD00208ChemSpider4027Chemical dataFormulaC15H25NO3 Mol. mass267.364 g/molSMILESeMolecules & PubChemPharmacokinetic dataBioavailability12%MetabolismHepaticHalf life3-7 hoursExcretionRenalTherapeutic considerationsLicence dataUS FDA:linkPregnancy cat.C(AU) C(US)Legal status℞ Prescription onlyRoutesoral ivMetoprolol is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension. It is marketed under the brand name Lopressor or Lopresor, respectively, by Novartis, and Toprol-XL (in the USA); Selokeen (in the Netherlands); as Minax by Alphapharm (in Australia), Metrol by Arrow Pharmaceuticals (in Australia), as Betaloc by AstraZeneca, as Neobloc by Unipharm (in Israel) and as Corvitol by Berlin-Chemie AG. A number of generic products are available as well. The active substance metoprolol is employed either as metoprolol succinate or metoprolol tartrate (whereas 100 mg metoprolol tartrate corresponds to 95 mg metoprolol succinate), respectively as prolonged-release or conventional-release formulation.// Physical propertiesMetoprolol has a very low melting point, around 45 degrees Celsius (as determined by Differential scanning calorimetry). Because of this metoprolol is always manufactured in a salt-based solution, as drugs with melting points below 100 degrees Celsius are difficult to work with in a manufacturing environment. The free base exists as a waxy white solid, where the tartrate salt is finer crystalline material. PharmacologySelectiveModerately LipophilicWithout intrinsic sympathomimetic activity (ISA)With weak membrane stabilizing activityShort half-life, therefore must be taken at least twice daily or as a Slow-release preparation.Decreases Heart Rate, Contractility and Cardiac Output, therefore decreasing blood pressure IndicationsEssential hypertensionTachycardiaCoronary heart disease (prevention of angina attacks)Secondary prevention after a myocardial infarctionTreatment of heart failure.Migraine prophylaxisVasovagal syncopeAdjunct in treatment of hyperthyroidismDue to its selectivity in blocking the beta1 receptors in the heart, metoprolol is also prescribed for off-label use in performance anxiety, social anxiety disorder, and other anxiety disorders. Side effectsTransient effects include dizziness, lightheadedness, drowsiness, tiredness, diarrhea, unusual dreams, ataxia, trouble sleeping, and vision problems. It may also reduce blood flow to the hands and feet, causing them to feel numb and cold; smoking may worsen this effect.Serious side effects that are not to be tolerated for any length of time include symptoms of a very slow heartbeat (less than 50 bpm) (e.g. persistent dizziness, fainting, unusual fatigue), bluish discoloration of the fingers and toes, numbness/tingling/swelling of the hands or feet, sexual dysfunction, erectile dysfunction (impotence), hair loss, mental/mood changes, trouble breathing, cough, and increased thirst. Other highly unlikely symptoms include easy bruising or bleeding, persistent sore throat or fever, yellowing skin or eyes, stomach pain, dark urine, and persistent nausea. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness. Taking it with alcohol might cause mild body rashes and therefore is not recommended.
- Your body then begins to store fat and use carbohydrates (sugar) as fuel.Blood Pressure/CholesterolAbana, Inderal, Lopressor, Toprol XL, Cozaar, Norvasc, LipitorInformation resources about zetia, zestril and lopressorMetoprolol is the generic name for two common drugs. Another brand name for this drug is Lopressor. This drug is frequently used to treat those who suffer from migraines. - Like Miracle Grow on plants, drugs such as Toprol-XL, Lopressor (metoprolol), Tenormin (atenolol), and Coreg (carvedilol) serve as fat fertilizer for the human body. Some are really bad, like the drugs used to lower blood pressure..Comprehensive description on high blood pressure medication Lopressor and its side-effectsNot all prescription drugs are bad. One is Toprol XL, traditionally prescribed for those who suffer from
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Learn about the prescription medication Lopressor (Metoprolol Tartrate), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.
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