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This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unverifiable material may be challenged and removed. (July 2008)BenzphetamineSystematic (IUPAC) name(2S)-N-benzyl-N-methyl-1-phenylpropan-2-amineIdentifiersCAS number156-08-1ATC code ?PubChem2341DrugBankAPRD00759Chemical dataFormulaC17H21N Mol. mass239.355 g/molSMILESeMolecules & PubChemPharmacokinetic dataBioavailability ?Protein binding75–99%Metabolism ?Half life ?Excretion ?Therapeutic considerationsPregnancy cat.?Legal statusSchedule III(US)Routes ?Benzphetamine (brand name Didrex) is an anti-obesity drug marketed under this brand in the USA by Pharmacia. Benzphetamine is used as a short term adjunct in management of exogenous obesity. It is closely related to amphetamine. PharmacologyBenzphetamine is a sympathomimetic amine, and is classified as an anorectic. The main function of this drug is to reduce appetite, which in turn reduces caloric intake. This drug can cause vivid hallucinations if taken for the wrong purpose.Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Amphetamine and related sympathomimetic medications (such as benzphetamine) are thought to stimulate the release of norepinephrine and/or dopamine from storage sites in nerve terminals in the lateral hypothalamic feeding center, thereby producing a decrease in appetite. This release is mediated by the binding of benzphetamine to centrally located adrenergic receptors. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. ContraindicationsBenzphetamine is contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyper-thyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. Benzphetamine should not be given to patients who are in an agitated state or who have a history of drug abuse. Controlled substance classificationBenzphetamine is unique in its classification as a Schedule III drug in the United States. (Most members of the amphetamine family are classified in the more highly-regulated Schedule II.) It's notable that benzphetamine is metabolized by the human body into amphetamine and methamphetamine metabolites, making it one of the very few drugs to undergo in vivo conversion to a substance of higher addiction and abuse potential. Benzphetamine itself does not have a such a high recreational abuse potential (Schedule III) because any administration route (ingested, insufflated, injected, etc.) would still have a sustained release due to the amount of time it would take the liver to metabolize it into amphetamine and methamphetamine.v • d • eStimulantsAlkylaminesCyclopentamine • Geranamine • Heptaminol • Isometheptene • Octodrine • Propylhexedrine • Tuaminoheptane (Tuamine)Alphapyrrolidinylalkiophenonesα-PPP • MDPPP • MDPV • MPBP • MPHP • MPPP • MOPPP • PyrovaleroneCholinergicsABT-089 • ABT-418 • Anabasine • Arecoline • Cotinine • Cytisine • Dianicline • Epibatidine • Epiboxidine • GTS-21 • Ispronicline • Nicotine • Rivanicline • TC-5619 • Tebanicline • VareniclineConvulsantsBicuculline • DMCM • Flurothyl • Gabazine • Pentetrazol • Picrotoxin • Strychnine • ThujoneEugeroicsAdrafinil • Armodafinil • Carphedon • ModafinilPhenethylamines1-Phenyl-2-methylaminobutan-1-one • 2-Phenyl-3-aminobutane • 2-Phenyl-3-methylaminobutane • 4-Bromomethcathinone • 4-FA • 4-Fluoromethamphetamine • 4-Fluoromethcathinone • 4-Ethylamphetamine • 4-Hydroxyephedrine (Oxilofrine) • 4-Methylamphetamine • 4-Methylmethamphetamine • Mephedrone (4-MMC) • 4-MTA • Alfetamine • Alpha-ethyl-phenethylamine • Amfepentorex • Amphechloral • Amphetamine (Dextroamphetamine, Adderall) • Amphetaminil • Benfluorex • Benzphetamine • β-Methylphenethylamine • Bupropion • Cathinone • Chlorphentermine • Clenbuterol • Clobenzorex • Clortermine • Diethylcathinone (Diethylpropion) • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone • Ephedrine • Epinephrine • Ethcathinone • Ethylamphetamine • Fenbutrazate • Fencamine • Fenethylline • Fenfluramine • Fenproporex • Fludorex • Furfenorex • Levomethamphetamine • Lisdexamfetamine • MDMA (Ecstasy) • Mefenorex • Mephentermine • Methamphetamine • Methcathinone • Methoxyphedrine • Methoxyphenamine • Methylone • Norfenefrine • Octopamine • Ortetamine • Parahydroxyamphetamine • PCA • PIA • PMA • PMEA • PMMA • PPAP • Phendimetrazine • Phenmetrazine • Phenpentermine • Phenpromethamine • Phentermine • Phenylephrine • Phenylpropanolamine • Propylamphetamine • Pseudoephedrine • Selegiline • Synephrine • Tiflorex • XylopropaminePhenylaminooxazoles4-Methyl-aminorex • Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • ThozalinonePiperazines2C-B-BZP • BZP • GBR-12783 • GBR-12935 • GBR-13069 • GBR-13098 • GBR-13119 • MeOPP • MBZP • VanoxerinePiperidines2-Benzylpiperidine • 4-Benzylpiperidine • Desoxypipradrol • Diphemethoxidine • Ethylphenidate • HDMP-28 • (-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate • Methylphenidate (Dexmethylphenidate) • Nocaine • Phacetoperane (Levofacetoperane) • Pipradrol (Meretran)Tropanes3α-Bis-(4-fluorophenyl)methoxytropane • 3α-((4-Chlorophenyl)phenylmethoxy)tropane • 3-Pseudotropyl-4-fluorobenzoate • Altropane (IACFT) • Brasofensine • CFT (WIN 35,428) • β-CIT (RTI-55) • Cocaethylene • Cocaine • β-CPPIT • Dichloropane (RTI-111) • Difluoropine • FE-β-CPPIT • FP-β-CPPIT • Ioflupane (FPCIT) • Norcocaine • PIT • PTT • RTI-31 • RTI-32 • RTI-51 • RTI-112 • RTI-113 • RTI-121 (IPCIT) • RTI-126 • RTI-150 • RTI-171 • RTI-177 • RTI-336 • Tesofensine • Troparil (β-CPT, WIN 35,065-2) • Tropoxane • WF-23 • WF-33 • WF-60XanthinesAminophylline • Caffeine • Dimethazan • Paraxanthine • Theobromine • TheophyllineOthers2-Aminoindane • 5-(2-Aminopropyl)indole • Amfonelic acid • Amineptine • Amiphenazole • Bemegride • Benzydamine • BPAP • Bromantane • BTCP • BTQ • BTS 74,398 • Chlodantane • Clofenciclan • Cropropamide • Crotetamide • Cypenamine • Cyprodenate • Diclofensine • Dimethocaine • Diphenylprolinol • Etamivan • Fencamfamine • Feprosidnine • Gilutensin • GYKI-52895 • Hexacyclonate • Indanorex • Indatraline • Lefetamine • Leptacline • LR-5182 • Manifaxine • Mazindol • Meclofexonate • Mefexamide • Mesocarb • Naphthylisopropylamine • Nikethamide • Nomifensine • O-2172 • Phthalimidopropiophenone • Prolintane • Sibutramine • Yohimbine • ZylofuramineSee also Sympathomimetic aminesv • d • eAntiobesity preparations (A08) – see also anorecticCentrally actingAmfepramone • Benfluorex • Benzphetamine • Cathine • Clobenzorex • Dexfenfluramine • Fenfluramine • Lorcaserin • Mazindol • Phendimetrazine • Phentermine • Sibutramine • Tesofensine;cannabinoids (Rimonabant • Taranabant)Peripherally actingCetilistat • Dinitrophenol • Oleoyl-estrone • Orlistat • Simmondsin
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Jump start you weight loss regime with Didrex! Obesity is the reason behind many physical and psychological perplexities in the United States and the world over.
Didrex : Weight Loss :: Pill-Care!
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