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ClomifeneSystematic (IUPAC) name2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-ethanamineIdentifiersCAS number911-45-5ATC codeG03GB02PubChem2800DrugBankAPRD00880ChemSpider2698Chemical dataFormulaC26H28ClNO Mol. mass406 or 598.10 (with citrate)Pharmacokinetic dataBioavailabilityHigh (>90%)MetabolismHepatic (with enterohepatic circulation)Half life5-7 daysExcretionMainly renal, some biliaryTherapeutic considerationsPregnancy cat.B3 (Au), X (U.S.)Legal statusS4 (Au), POM (UK), ℞-only (U.S.)Routes50 mg tabletsClomifene (INN) or clomiphene (USAN and former BAN) or Clomid or Clomifert is a selective estrogen receptor modulator (SERM), used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome). Clomiphene citrate is marketed under various trade names including Clomid, Serophene, Milophene, etc.// Mode of actionClomifene acts by inhibiting the action of estrogen on the hypothalamus. Zuclomifene, the more active isomer (see below), binds to estrogen receptors and stays bound for long periods of time. This prevents normal receptor recycling and causes an effective reduction in hypothalamic estrogen receptor number. Since estrogen can no longer effectively feedback on the hypothalamus, GnRH secretion becomes more pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release. Increased gonadotropin levels cause growth of the ovarian follicle, followed by follicular rupture, otherwise known as ovulation.Clomifene can lead to multiple ovulation, and hence increasing the chance of twins (3-5% of births instead of normal ~1%). In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer and weight gain. ChemistryClomifene is a diastereomeric mixture of two geometric isomers, enclomifene (E-clomifene) and zuclomifene (Z-clomifene). Adverse effectsCommon adverse drug reactions associated with the use of clomifene (≥1% of patients) include: hot flashes, abdominal discomfort, visual blurring (dose-dependent), and/or reversible ovarian enlargement and cyst formation. Infrequent adverse effects (0.1–1% of patients) include: abnormal uterine bleeding, nausea, and/or vomiting. Rare adverse effects (<0.1% of patients) include: reversible alopecia and/or ovarian hyperstimulation syndrome. Use in bodybuildingClomifene is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, thereby blocking the effects of estrogen, i.e., gynecomastia. It also restores the body's natural production of testosterone. It is commonly used as a "recovery drug" and taken toward the end of a steroid cycle. Some users report that taking Clomid increases the amount of fluid produced during ejaculation.
This category includes products for breast enlargement (Breast Success), fertility stimulation (Clomid), treating fungal infections caused by Candida albicans and Cryptococcus neoformans (Diflucan), hormone therapy (Evista), men attraction (Euphoria perfume), treatment of severe vasomotor symptoms of the menopause (Premarin) and increasing a woman'Many people are worried that their infertility treatment drugs could cause ovarian cancer. Check with your clomid if any of these most .If you are interested in knowing if clomiphene citrate or Clomid causes hair loss, then you may also like to learn about the side effects that it gives for those aspiring mothers and one of the well-known side effects of Clomid is multiple births or the probability of having twins. Recent studies proven no link between taking infertility treatment drugs like Clomid, and ovarian cancer. With the cycles below we are trying to show you some reliable, mild and affordable ones..Clomid is the more popular brand for the drug, Clomiphene Citrate, a fertility that is supposed to induce ovulation in a woman. It is the number 1 solution for PCOS. Clomid is a proven fertility drug.. It is also a relatively safe and low risk medicine. In IUI (intrauterine insemination) is a common infertility procedure
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