Zyloprim
08 »
Zyloprim
AllopurinolSystematic (IUPAC) name3,5,7,8-tetrazabicyclo nona-3,5,9-trien-2-oneIdentifiersCAS number315-30-0ATC codeM04AA01PubChem2094DrugBankAPRD00435ChemSpider2010Chemical dataFormulaC5H4N4O Mol. mass136.112 g/molPharmacokinetic dataBioavailability78±20%Protein bindingNegligibleMetabolismhepatic (80% oxypurinol, 10% allopurinol ribosides)Half life2 hours (oxypurinol 18-30 hours)Excretion ?Therapeutic considerationsPregnancy cat.C(USA)Legal statusSchedule 6 (USA)Routestablet (100, 300 mg)Allopurinol is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout.// Mechanism of actionAllopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an enzyme inhibitor, inhibiting xanthine oxidase. Xanthine oxidase is responsible for the successive oxidation of hypoxanthine and xanthine resulting in the production of uric acid, the product of human purine metabolism. In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine, which are converted to closely related purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides causes feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol therefore decreases both uric acid formation and purine synthesis. UsesThe primary use of allopurinol is to treat hyperuricemia (excess uric acid in blood plasma) and its complications. Allopurinol does not alleviate acute attacks of gout, but is useful in chronic gout to prevent future attacks. Similarly, allopurinol commonly is used as prophylaxis with chemotherapeutic treatments, which can rapidly produce severe hyperuricemia. Other established indications for allopurinol therapy include ischaemic reperfusion injury, kidney stones with a uric acid component (uric acid nephrolithiasis) and protozoal infections (Leishmaniasis).Because allopurinol is not a uricosuric, it can be used in patients who have poor kidney function. However, allopurinol has two important disadvantages: its dosing is complex, and some patients will be hypersensitive to it. Therefore, use of this drug requires careful monitoring. MetabolismAllopurinol is rapidly metabolized by its target, xanthine oxidase, to its active metabolite oxypurinol, which is also an inhibitor of xanthine oxidase. Allopurinol is almost completely metabolized to oxypurinol within two hours of oral administration, whereas oxypurinol is slowly excreted by the kidneys over 18-30 hours. For this reason, oxypurinol is believed to be responsible for the majority of allopurinol's effect. Side effectsSide effects of allopurinol are rare, though significant when they occur. A small percentage of people develop a rash and must discontinue this drug. The most serious adverse effect is a hypersensitivity syndrome consisting of fever, skin rash, eosinophilia, hepatitis, worsened renal function and, in some cases, allopurinol hypersensitivity syndrome. Allopurinol is one of the drugs commonly known to cause Stevens-Johnson syndrome (SJS), and Toxic Epidermal Necrolysis Syndrome (TENS) which is an adverse drug reaction.Allopurinol can cause severe pancytopenia if given with azathioprine or mercaptopurine, due to inhibition of xanthine oxidase which metabolizes these drugs. Brand namesAllopurinol has been marketed in the United States since 1964. Allopurinol is marketed by Prometheus in the United States as Zyloprim, while in other countries it continues to be marketed by GlaxoSmithKline. Other brand names are Allohexal, Allosig, Progout, and Zyloric. In South Africa, Allopurinol is marketed under the brand name Puricos.
It works by lowering the body's production of uric acid..Buy Cheap Zyloprim online - CHEAPEST price on web!!! Zyloprim is a xanthine
Even more about Zyloprim
Zyloprim
Where to buy zyloprim online? discreet packaging, Always Special Offers in Our Online-Drugstore
Where to buy zyloprim online? discreet packaging, Always Special ...
Order zyloprim online. Looking for the Cheapest Medications? Our Pharmacy Store is the Right Place. You can check the prices, and then click on one of the images below to proceed ...
ваш_домен.ru • Просмотр темы - Where to buy ...
Your Best Drugstore. Always The Cheapest Offers in Our Pharmacy Store. Order zyloprim online. You can check the prices, and then click on one of the images below to proceed to the ...
wowfos.km.ru :: Просмотр темы - Where to buy zyloprim ...
Where to buy zyloprim online? The Lowest Pharmacy Offers, we offer a wide selection of payment methods, zyloprim
Where to buy zyloprim online? The Lowest Pharmacy Offers, we offer a ...
Where To Buy Zyloprim Online? The Lowest Pharmacy Offers, Always The Best Offers In Our Online Pharmacy Store, zyloprim
Comment:
