Vantin


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Vantin

CefpodoximeSystematic (IUPAC) name(6R,7R)-7-{amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclooct-2-ene-2-carboxylic acidIdentifiersCAS number82619-04-3ATC codeJ01DD13PubChem6335986Chemical dataFormulaC15H17N5O6S2 Mol. mass427.458 g/molPharmacokinetic dataBioavailability50%Protein binding21% to 29%MetabolismNegligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liverHalf life2 hoursExcretionRenal, unchangedTherapeutic considerationsPregnancy cat.B1(AU) B(US)Legal status℞-only(US)RoutesOralCefpodoxime (marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin, is an oral third generation cephalosporin. It is active against most Gram positive and Gram negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and fragilis]]. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.Pfizer, the parent company of Pharmacia & Upjohn, markets Cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day. In India, for children it is sold under the trade name of PECEF (Dr Reddy's) in 50mg & 100mg DT & DS forms (FGP) and for adult, it is sold under the trade name of PECEF 200 (Dr Reddy's) Doxicef 200 (Lupin) in 200mg.
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