Singulair
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Singulair
MontelukastSystematic (IUPAC) name2-phenyl]-3-propyl]sulfanylmethyl]cyclopropyl]acetic acidIdentifiersCAS number158966-92-8ATC codeR03DC03PubChem60951DrugBankAPRD00434Chemical dataFormulaC35H36ClNO3S Mol. mass586.184 g/molSMILESeMolecules & PubChemPharmacokinetic dataBioavailability63% to 73%Protein binding99%MetabolismHepatic (CYP3A4 and CYP2C9-mediated)Half life2.7-5.5 hoursExcretionBiliaryTherapeutic considerationsPregnancy cat.B (U.S.), B1 (Au)Legal status℞-only (U.S.), POM (UK), S4 (Au)RoutesOralMontelukast (trade name Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast is a CysLT1 antagonist; that is it blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific focus of operation, it does not interact with other allergy medications such as theophylline.Another leukotriene receptor antagonist is zafirlukast (Accolate), taken once daily. Zileuton (Zyflo), an asthma drug taken four times per day, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.The Mont in Montelukast stands for Montreal, the place where Merck developed the drug // Side effectsSide effects include gastrointestinal disturbances, hypersensitivity reactions, sleep disorders and increased bleeding tendency, aside from many other generic adverse reactions. Its use is associated with a higher incidence of Churg-Strauss syndrome (whether or not this drug is 'unmasking' subclinical Churg-Strauss is as yet uncertain). In March, 2008 the FDA announced that it would investigate whether mood changes and suicidal thoughts are possible side effects of drugs in this class, including the popular drug Singulair, which currently lists these side effects. On January 13, 2009, the FDA indicated that their review of clinical trials does not suggest Singulair or similar medicines cause suicide or suicidal thought, although it was continuing to review data to determine if the class of drugs causes other potential psychiatric problems. Use with loratadine and/or montelukastSchering-Plough and Merck have sought permission to market a combined tablet with loratadine (Claritin) and montelukast (Singulair), as many patients combine the two themselves. However, the FDA has found no benefit from a combined pill for seasonal allergies over taking the two drugs in combination, and on April 25, 2008, issued a "not approvable" letter for the combination. Patent(s)Singulair is covered by U.S. Patent No. 5,565,473 which is set to expire (by extension) on February 3, 2012.
WASHINGTON - The Food and Drug Administration (FDA) is reviewing the reported incidents of a three or four patients experiencing mood changes that led to suicidal behavior.Singulair Review for AsthmaNow I know there is no official link between Singulair and suicidal thoughts, but let me tell you my brother Mattâs story. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness.. Singulair is used to treat asthma and seasonal allergies.The Food and Drug Administration is investigating anecdotal reports that people who use Singulair, the popular asthma and allergy drug, are at greater risk for suicidal thoughts and suicide. Ever since the report broke on the news, I have decided to talkFDA said it is reviewing reports involving mood changes, suicidal behavior and suicide in patients who have taken Singulair. But the WBZ I-Team found out that some patients say they're suffering horrible side effects from the drug. Discusses possible treatment options as well.. The Food and Drug Administration (FDA) is reviewing the reported incidents of a three or four patients experiencing mood changes that led to suicidal behavior.Singulair Review for AsthmaNow I know there is no official link between Singulair and suicidal thoughts, but let me tell you my brother Mattâs
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Singulair
ИНСТРУКЦИЯ для специалистов по медицинскому применению лекарственного препарата СИНГУЛЯР ...
СИНГУЛЯР - SINGULAIR
Find information about SINGULAIR, a once-a-day medication for the treatment of asthma and seasonal allergies. Learn more about SINGULAIR asthma and seasonal allergy medication for ...
Find information about a medication that treats seasonal allergies or ...
SINGULAIR ® (montelukast sodium) is a prescription medicine approved to help control asthma in adults and children as young as 12 months and to help relieve the symptoms of indoor ...
Treatment of seasonal allergies and information for parents at ...
This Web site is intended for non-U.S. physicians only; it is not intended for U.S. physicians (U.S. physicians should visit www.singulair.com).
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