Plendil
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Plendil
FelodipineSystematic (IUPAC) name3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylateIdentifiersCAS number72509-76-3ATC codeC08CA02PubChem3333DrugBankAPRD00374Chemical dataFormulaC18H19Cl2NO4 Mol. mass383.069 g/molPharmacokinetic dataBioavailability>95% MetabolismHepaticHalf life ??ExcretionRenalTherapeutic considerationsPregnancy cat.C(US)Legal status℞ Prescription onlyRoutesOralFelodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). It is marketed with the brand name Plendil by AstraZeneca. The formulation patent for the substance expired in 2007.AstraZeneca dropped Plendil from its support and AZ&Me free Rx access program in October 2008. InteractionsRecent findings have suggested that felodipine in combination with grapefruit juice can cause toxic effects. Oral administration of felodipine is first metabolized in the gastrointestinal tract and liver by the enzyme CYP3A4. Grapefruit juice contains bergamottin which is found to have an inhibiting effect over this enzyme and as a result the bioavailability of the drug increases, raising the risk for abnormal side effects.
Generic Plendil is a calcium channel blocker used to treat high blood pressure.. Tablets PLENDIL provide extended release of felodipine
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