Phenergan
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Phenergan
PromethazineSystematic (IUPAC) namedimethylamineIdentifiersCAS number60-87-758-33-3 (hydrochloride)ATC codeD04AA10 R06AD02, R06AD05PubChem4927DrugBankAPRD00601ChemSpider4758Chemical dataFormulaC17H20N2S Mol. mass284.42 g/molPharmacokinetic dataBioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailabilityProtein binding93%MetabolismHepatic glucuronidation and sulfoxidationHalf life16-19 hoursExcretionRenal and biliaryTherapeutic considerationsPregnancy cat.C(AU) C(US)Legal statusP(UK) â„ž-only(US)(injection POM(UK))RoutesOral, rectal, IV, IM, topicalPromethazine is a first-generation H1 receptor antagonist, antihistamine and antiemetic medication. It can also have strong sedative effects although it is rarely used specifically for this. It is a prescription drug in the United States, but is available over the counter in the United Kingdom, Switzerland, and many other countries (brand names Phenergan, Promethegan, Romergan, Fargan, Farganesse, Prothiazine, Avomine, Atosil, Receptozine, Lergigan).Chemically, promethazine hydrochloride (HCl) appears as a white to faint yellow crystaline powder which is practically odorless. Slow oxidation may occur upon prolonged exposure to air usually causing blue discoloration. Promethazine as the hydrochloride salt is freely soluble in water and somewhat soluble in alcohol.// IndicationsAs a sedative.For preoperative sedation and to counteract postnarcotic nausea.As antiallergic medication to combat hay fever, allergic rhinitis, etc. To treat allergic reactions it can be given alone or in combination with oral decongestants like pseudoephedrine.As an adjunct treatment for anaphylactoid conditions (IM/IV route preferred).Together with codeine or dextromethorphan against cough.As a motion sickness or seasickness remedy when used with Ephedrine or Pseudoephedrine.To combat moderate to severe morning sickness and hyperemesis gravidarum. In the UK promethazine is drug of first choice, being preferred as an older drug with which there is a greater experience of use in pregnancy (second line being metoclopramide or prochlorperazine).Previously it was used as an antipsychotic., although it is generally not administered for this purpose now; promethazine has only approximately 1/10 of the antipsychotic strength of chlorpromazine. ContraindicationsPromethazine should not be given to children under two years of age; there is potential for fatal respiratory depression in this age group.Hypersensitivity to phenothiazinesClosed angle glaucomaIntoxication with alcohol or other central depressantsSevere hypotension or shockComa due to any reasonSeverely impaired liver functionUrine hesitancy due to enlargement of the prostate gland Mechanism of actionPromethazine is a phenothiazine derivative that competitively blocks histamine H1 receptors without blocking the secretion of histamine.It has sedative, anti-motion-sickness, anti-emetic, and anti-cholinergic effects Side effectsSome common side effects include:Blurred visionConfusion in the elderlyDrowsiness, dizziness, fatigue, more rarely vertigoDry mouthSeizures (extremely rare)Neuroleptic malignant syndrome (extremely rare)Respiratory depression in patients under age of 2 and in those with severely compromised pulmonal functionConstipationEuphoria (very rare with high IV doses and/or coadministration with opioids/CNS depressants)Restless legs ParesthesiaIt is recommended that promethazine only be given through an existing intravenous set in a large vein and diluted to concentration no greater than 25mg per mL, not to exceed a rate of administration of 25mg a min. Serious complications including those listed above have resulted from improper parenteral administration, including those requiring surgical intervention and amputation. Laboratory examinationsAll patients should have their blood pressure measured frequently. During long-term therapy, blood cell counts, liver function studies, EKG, and EEG are recommended. The intervals should be determined according to the risk profile of the patient. In high doses, promethazine can create auditory and visual hallucinations causing panic and intense fear. Case LawThe U.S. Supreme Court accepted a case involving promethazine that influences product liability. A woman suffering from a migraine was administered Wyeth's Phenergan via IV push. The drug was injected improperly resulting in gangrene and subsequent amputation of her right arm below the elbow. A state jury awarded her $6 million in punitive damages. The case was appealed to the Supreme Court on grounds of federal pre-emption and substantive due process. The Supreme Court upheld the lower courts' rulings stating that "Wyeth could have unilaterally added a stronger warning about IV-push administration" without acting in opposition to federal law.
Phenergan is a drug used to treat nausea. On Wednesday evening he took Phenergan and Ambien, a sleep aid.Wyeth (soon to be joined with Pfizer) lost a court battle this week where a woman lost an arm because of misuse of their drug Phenergan.By a 6-3 vote, the High Court upheld a ruling awarding $6. "Apparently, I was disoriented from the medication.7 million to a Vermont woman who lost her arm after a botched injection of Wyeth Pharmaceutical’s anti-nausea drug, Phenergan., I drove the few blocks to the Capitol Complex believing I needed to vote," he said. "Some time around 2:45 a.Diane Levine blames for a botched injection of the Wyeth-made drug Phenergan that led doctors to amputate her right arm in 2000.m. Diana Levine’s case against drug giant Wyeth will be heard by the Supreme Court today, the outcome of which has the potential to change the way defective drug lawsuits are handled. A Vermont jury awarded Levine $6." The officers involved in the accident were instructed by an official "above the rank of patrolman" to take Kennedy home. Additionally, giants Schering-Plough and Merck combine.7 million,A musician lost her right arm due to a bad injection
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Phenergan
Learn about the prescription medication Phenergan (Promethazine), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.
Phenergan (Promethazine) Drug Information: Uses, Side Effects, Drug ...
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PHENERGAN est utilisé pour traiter certaines insomnies. Il est aussi utilisé pour traiter les manifestations allergiques (rhinite, urticaire, conjonctivite) ou pour lutter contre ...
PHENERGAN - Prométhazine - Doctissimo
It is a prescription drug in the United States, but is available over the counter in the United Kingdom, Switzerland, and many other countries (brand names Phenergan, Promethegan, ...
Promethazine - Wikipedia, the free encyclopedia
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