Mexitil
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Mexitil
MexiletineSystematic (IUPAC) name1-(2,6-dimethylphenoxy)propan-2-amineOR2-(2-aminopropoxy)-1,3-dimethylbenzeneIdentifiersCAS number31828-71-4ATC codeC01BB02PubChem4178DrugBankAPRD00242Chemical dataFormulaC11H17NO Mol. mass179.259 g/molPharmacokinetic dataBioavailability90%Protein binding50-60%MetabolismHepatic (CYP2D6 and 1A2- mediated)Half life10-12 hoursExcretionRenal (10%)Therapeutic considerationsPregnancy cat.B1(AU) C(US)Legal statusPOM(UK)RoutesOral, IVMexiletine (INN, sold under the trade name Mexitil) belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by blocking sodium channels.Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002) and is also effective for treating muscle stiffness resulting from myotonia congenita (Thomsen disease) or myotonic dystrophy (Steinert's disaese).
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Mexitil
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