Mentax
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Mentax
ButenafineSystematic (IUPAC) name(methyl)(naphthalen-1-ylmethyl)amineIdentifiersCAS number101828-21-1ATC codeD01AE23PubChem2484DrugBankAPRD00833ChemSpider2390Chemical dataFormulaC23H27N Mol. mass317.47 g/molPharmacokinetic dataBioavailability ?MetabolismHepaticHalf life35-100 hoursExcretion ?Therapeutic considerationsPregnancy cat.?Legal statusRoutestopicalButenafine hydrochloride is a synthetic benzylamine antifungal, marketed under the trade names Mentax, Butop(India) and is the active ingredient in Schering-Plough's Lotrimin Ultra. It is structurally related to synthetic allylamine antifungals such as terbinafine. PharmacologyButenafine hydrochloride is an odorless white crystalline powder that is freely soluble in methanol, ethanol, and chloroform, and slightly soluble in water.Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak out. IndicationsButenafine is indicated for the topical treatment of tinea (pityriasis) versicolor due to M. furfur, as well as athlete’s foot (Tinea pedis), ringworm (Tinea corporis) and jock itch (Tinea cruris) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans. It has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, clotrimazole, and tolnaftate.It also displays superior activity against Candida albicans when compared against terbinafine and naftifine. Butenafine demonstrates low minimum inhibitory concentrations against cryptococcus and aspergillus.Butenafine is typically available as a 1% topical cream. Typical usageFor 1% creamfor adults and children 12 years and olderwash the affected skin with soap and water and dry completely before applyingapply once a day to affected skin for 2 weeks or as directed by a doctorwash hands after each usechildren under 12 years: ask a doctorv • d • eAntifungals (D01 and J02)Wall/membraneErgosterolinhibitorsAzoles(lanosterol 14alpha-demethylase inhibitors)Imidazolestopical: Bifonazole, Clomidazole, Clotrimazole, Croconazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole, Neticonazole, Oxiconazole, Sertaconazole, Sulconazole, TioconazoleTriazolestopical: (Fluconazole, Fosfluconazole)systemic: (Itraconazole, Posaconazole, Voriconazole)Benzimidazolestopical: ThiabendazolePolyene antimycotics(ergosterol binding)topical: (Natamycin, Nystatin)systemic: (Amphotericin B)Allylamines(squalene monooxygenaseinhibitors)topical: (Amorolfine, Butenafine, Naftifine, Terbinafine)systemic: (Terbinafine)β-glucan synthaseinhibitorsechinocandins (Anidulafungin, Caspofungin, Micafungin)IntracellularPyrimidine analogues/Thymidylate synthase inhibitorsFlucytosineMitotic inhibitorsGriseofulvinOthersBromochlorosalicylanilide · Methylrosaniline · Tribromometacresol · Undecylenic acid · Polynoxylin · Chlorophetanol · Chlorphenesin · Ticlatone · Sulbentine · Ethyl hydroxybenzoate · Haloprogin · Salicylic acid · Selenium sulfide · Ciclopirox · Amorolfine · Dimazole · Tolnaftate · Tolciclate · FlucytosineTea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle • Whitfield's ointmentPCP: Pentamidine • Dapsone • Atovaquone This antimicrobial-related article is a stub. You can help Wikipedia by expanding it.
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Opinie "W obecnych czasach żadna chyba działalność gospodarcza nie może liczyć na rozwój, jeśli nie zaistnieje w sieci. My, dzięki mentax.pl wejście w świat internetu ...
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Mentax. From $21.26 per pill. Mentax is used for treating certain fungal infections of the skin. It may also be used to treat other conditions as determined by your doctor,...
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Wybierz: Dane identyfikacyjne Historia Misja : Opinie "W obecnych czasach żadna chyba działalność gospodarcza nie może liczyć na rozwój, jeśli nie zaistnieje w sieci.
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