Mavik
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Mavik
TrandolaprilSystematic (IUPAC) name(2S,3aR,7aS)-1-amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acidIdentifiersCAS number87679-37-6ATC codeC09AA10PubChem5484727DrugBankAPRD01269Chemical dataFormulaC24H34N2O5 Mol. mass430.537 g/molPharmacokinetic dataBioavailability ?Protein bindingTrandolapril 80%(independent of concentration)Trandolaprilat 65 to 94%(concentration-dependent)MetabolismHepaticHalf life6 hours (trandolapril)10 hours (trandolaprilat)ExcretionFecal and renalTherapeutic considerationsPregnancy cat.D(US)Legal status℞ Prescription onlyRoutesOralTrandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions. It is marketed by Abbott Laboratories with the brand name Mavik.// PharmacologyTrandolapril is a prodrug that is deesterified to trandolaprilat. It is believed to exert its antihypertenive effect through the renin-angiotensin-aldosterone system. Trandolapril has a half life of about 6 hours, and trandolaprilat has a half life of about 10. Trandolaprilat has about 8 times the activity of its parent drug. Approximately 1/3 of Trandolapril and its metabolites are excreted in the urine, and about 2/3 of Trandolapril and its metabolites are excreted in the feces. Serum protein binding of trandolapril is about 80%. Mode of actionTrandolapril acts by competitive inhibition of Angiotensin Converting Enzyme (ACE), a key enzyme in the renin-angiotensin system (RAS pathway) which plays an important role in regulating blood pressure. See ACE inhibitors for more information. Side effectsSide effects reported for Trandolapril include nausea, vomiting, or diarrhea; headache; dry cough; dizziness or lightheadedness when sitting up or standing; hypotension or fatigue. Possible Drug InteractionsPatients also on diuretics may experience an excessive reduction of blood pressure after initiation of therapy with Trandolapril. Trandolapril can reduce potassium loss caused by thiazide diuretics, and increase serum potassium when used alone. Therefore hyperkalemia is a possible risk. Increased serum lithum levels can occur in patients who are also on lithium. For more information see angiotensin converting enzyme (ACE) inhibitors. Contraindications and PrecautionsSee ACE inhibitors for more information. Pregnancy and Lactation Category DTrandolapril is teratogenic and can cause birth defects and even death of the developing fetus. The highest risk to the fetus is during the second and third trimester. When pregnancy is detected, Trandolapril should be discontinued as soon as possible.Trandolapril should not be administed to nursing mothers.
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Learn about Mavik (Trandolapril), including potential side effects and drug interactions. ... Why is Mavik prescribed? Mavik controls high blood pressure. It is effective when used ...
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This information is intended for U.S. residents only. MAVIK ® (Trandolapril Tablets) * only • BOX WARNING • DESCRIPTION • CLINICAL PHARMACOLOGY • INDICATIONS AND USAGE ...
This information is intended for U.S. residents only.
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