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CiclopiroxSystematic (IUPAC) name6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-oneIdentifiersCAS number29342-05-0ATC codeD01AE14 G01AX12PubChem2749DrugBankAPRD00871ChemSpider2647Chemical dataFormulaC12H17NO2 Mol. mass207.269 g/molPharmacokinetic dataBioavailability<5% with prolonged useProtein binding94 to 97%Metabolism ?Half life1.7 hoursExcretion ?Therapeutic considerationsPregnancy cat.?Legal status℞-only(US) Rx-only (CA)RoutesTopical (applied as a nail lacquer)Ciclopirox olamine (also called Batrafen Loprox, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. Mechanism of actionIn contrast to the azoles and other antimycotic drugs, the mechanism of action of ciclopirox is only poorly understood. However, loss of function of certain catalase and peroxidase enzymes has been implicated the mechanism of action, as well as various other components of cellular metabolism. In a study conducted to further elucidate ciclopirox's mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from interpretation of the effects of both the drug treatment and mutation suggested that ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase.. It is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur. Initial results show similar efficacy to ketoconazole with a relative increase in subjective symptom relief due to its inherent anti-inflammatory properties.

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Loprox

LOPROX® Shampoo is indicated for the topical treatment of seborrheic dermatitis of the scalp in adults.

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LOPROX® (ciclopirox) Shampoo 1%

Learn about the prescription medication Loprox Gel (Ciclopirox Gel), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.

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Loprox Gel (Ciclopirox Gel) Drug Information: Uses, Side Effects, Drug ...

Learn about Loprox from the publishers of the Physicians Desk Reference. Find prescription drug information resources including interactions, side effects, symptoms, treatment, and ...

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Loprox | Prescription Drug Information, Side Effects | PDRHealth

Lo·prox (l pr ks) A trademark for the drug ciclopirox olamine. Loprox, trademark for an antifungal (ciclopirox olamine). Loprox® Ciclopirox Infectious disease A topical for tinea ...

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Loprox - definition of Loprox in the Medical dictionary - by the Free ...

Summary of LOPROX ® Shampoo Safety Information LOPROX ® Shampoo is approved for the topical treatment of seborrheic dermatitis of the scalp in adults.

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