Leukeran
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Leukeran
ChlorambucilSystematic (IUPAC) name4-benzenebutanoic acidIdentifiersCAS number305-03-3ATC codeL01AA02PubChem2708DrugBankAPRD00115ChemSpider2607Chemical dataFormulaC14H19Cl2NO2 Mol. mass304.212 g/molPharmacokinetic dataBioavailability ?MetabolismHepaticHalf life1.5 hoursExcretionN/ATherapeutic considerationsPregnancy cat.D(US)Legal status℞ Prescription onlyRoutesOralChlorambucil (marketed as Leukeran by GlaxoSmithKline) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. It is a nitrogen mustard alkylating agent and can be given orally.In the past, chlorambucil has been used for treating some types of non-Hodgkin lymphoma, Waldenström macroglobulinemia, polycythemia vera, trophoblastic neoplasms, and ovarian carcinoma. It also has been used as an immunosuppressive drug for various autoimmune and inflammatory conditions, such as nephrotic syndrome. Its current use is mainly in chronic lymphocytic leukemia, as it is well tolerated by most patients, though chlorambucil has been largely replaced by fludarabine as first-line treatment in younger patients. Side EffectsBone marrow suppression (anemia, neutropenia, thrombocytopenia) is the most commonly occurring side effect of chlorambucil. Withdrawn from the drug, this side effect is typically reversible. Like many alkylating agents, chlorambucil has been associated with the development of other forms of cancer.Less commonly occurring side effects include:Gastrointestinal Distress (nausea, vomiting, diarrhea, and oral ulcerations).Central Nervous System: Seizures, tremors, muscular twitching, confusion, agitation, ataxia, and hallucinations.Skin reactionsHepatotoxicityInfertility
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Leukeran
ЛЕЙКЕРАН (leukeran) Рег. номер: П №011903/01-2000 27.04.00: Состав и форма ...
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leukeran: noun: an alkalating agent (trade name Leukeran) used to treat some kinds of cancer [syn: chlorambucil]
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leukeran definition | Dictionary.com
Thesaurus Legend: Synonyms Related Words Antonyms. Noun: 1. Leukeran - an alkalating agent (trade name Leukeran) used to treat some kinds of cancer. chlorambucil
Leukeran - definition of Leukeran by the Free Online Dictionary ...
Product information on the cancer drug chlorambucil, from GlaxoSmithKline. [PDF]
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