Kytril
08 »
Kytril
GranisetronSystematic (IUPAC) name1-methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclononan-3-yl)-1H-indazole-3-carboxamideIdentifiersCAS number109889-09-0ATC codeA04AA02PubChem3510DrugBankAPRD01002Chemical dataFormulaC18H24N4O Mol. mass312.41 g/molPharmacokinetic dataBioavailability60%Protein binding65%MetabolismHepaticHalf life3–14 hoursExcretionRenal 11–12%, faecal 38%Therapeutic considerationsPregnancy cat.B1 (Au),Legal statusS4 (Au), POM (UK), ℞-only (U.S.)RoutesOral, intravenous, transdermalGranisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.Granisetron was developed by chemists working at the British drug company Beecham around 1988 and is available as a generic. It is produced by Roche Laboratories under the trade name Kytril. The drug was approved in the United Kingdom in 1991 and in United States in 1994 by the FDA.A granisetron transdermal patch with the trade name Sancuso was approved by the US FDA on September 15, 2008. Sancuso is manufactured by ProStrakan, Inc., a pharmaceutical company headquartered in Bedminster, NJ with global headquarters in Scotland.Granisetron breaks down slowly, staying in the body for a long time. One dose usually lasts 4 to 9 hours and is usually administered once or twice daily. This drug is removed from the body by the liver and kidneys.// IndicationsChemotherapy-induced nausea and vomiting5-HT3 receptor antagonists are the primary drugs used to treat and prevent chemotherapy-induced nausea and vomiting. Many times they are given intravenously about 30 minutes before beginning therapy.Post-operative and post-radiation nausea and vomitingIs a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritisTreatment of Cyclic vomiting syndrome although there are no formal trials to confirm efficacy. Adverse effectsGranisetron is a well-tolerated drug with few side effects. Headache, dizziness, and constipations are the most commonly reported side effects associated with its use. There have been no significant drug interactions reported with this drug's use. It is broken down by the liver's cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system.
This is just insane. Find Kytril (Granisetron) medication description and details on prescription drugs..Kytril offers you the confidence to control these distressing side effects of cancer treatments. This post compares the price of the drug 'Kytril' to Gold and Platinum.The
Even more about Kytril
Kytril
WELCOME TO KYTRIL.COM You don't have to suffer from nausea and vomiting (also called emesis) as a result of chemotherapy and radiation therapy.
Kytril: Home
The most frequently reported clinical adverse events occurring in >5% of patients receiving Kytril were headache, constipation, asthenia, diarrhea, abdominal ...
Kytril: Site Map
Learn about the prescription medication Kytril (Granisetron), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.
Kytril (Granisetron) Drug Information: Uses, Side Effects, Drug ...
kytril КИТРИЛ. Противорвотный препарат. Гранисетрон является селективным антагонистом 5 ...
КИТРИЛ - KYTRIL - KITRIL - Антагонист ...
Китрил Kytril инструкция по применению. - Медицинская библиотека ... Вся информация на этом сайте ...
Comment:
media
