Famvir
08 »
Famvir
FamciclovirSystematic (IUPAC) name2--4-(2-amino-9H-purin-9-yl)butyl acetateIdentifiersCAS number104227-87-4ATC codeJ05AB09 S01AD07PubChem3324DrugBankAPRD00600Chemical dataFormulaC14H19N5O4 Mol. mass321.332 g/molPhysical dataMelt. point103 °C (217 °F)Pharmacokinetic dataBioavailability75–77%Protein binding20-25%MetabolismHepatic, circulation, intestinal wall (to penciclovir)Half life2–2.3 hoursExcretionRenal, faecalTherapeutic considerationsPregnancy cat.B1 (Au), B (U.S.)Legal statusS4 (Au), POM (UK), ℞-only (U.S.)RoutesOralFamciclovir (INN) (pronounced /fæmˈsaɪkloʊvɪr/) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Schering-Plough).On August 24, 2007, the United States Food and Drug Administration approved the first generic version of famciclovir. Generic Famciclovir Tablets (125 mg, 250 mg, 500 mg) are manufactured by Kfar-Sava, Israel-based TEVA Pharmaceuticals. // Clinical use Indications and dosage formsFamciclovir comes as a tablet to take by mouth. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days. It is also sometimes given in one single large dose as opposed to several days of scheduled small doses. Among other side effects, Famciclovir may cause an upset stomach. Take famciclovir with food or milk. Adverse effectsSide effects: mild to extreme stomach upset, headaches, mild fever Off-label use in early treatment of herpesSeveral studies in humans and mice provide evidence that early treatment with Famciclovir soon after the first infection with herpes can significantly lower the chance of future outbreaks of herpes. Use of Famciclovir in this manner has been shown to reduce the amount of latent virus in the neural ganglia. A review of human subjects treated for five days with Famciclovir 250 mg three times daily during their first herpes episode found that only 4.2 percent experienced a recurrence within six months after the first outbreak, a five-fold decrease compared to the 19 percent recurrence in acyclovir-treated patients. Despite these promising results, early Famciclovir treatment for herpes in this or similar dosage regimes has yet to find mainstream adoption. As a result, some doctors and patients have opted for off-label use. One suggested regime is Famciclovir at 10-20mg/kg per day for 5-10 days, with treatment to commence as soon as possible after the first herpes infection(not the first symptoms or outbreak), and the most effective time for initiating treatment to be five days or less after the first herpes infection. However, the window of opportunity for this treatment is only a few months after first infection with the virus, following this the potential effect on latency drops to zero. Footnotes^ "Recent Product Launches, Teva Pharmaceuticals USA". http://www.tevausa.com/default.aspx?pageid=75. Retrieved on 2008-02-21. ^ a b "MedlinePlus Drug Information: Famciclovir" (HTML). http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a694038.html. Retrieved on 2007-06-12. ^ The effects of antiviral therapy on the distribution of herpes simplex virus type 1 to ganglionic neurons and its consequences during, immediately following and several months after treatment""^ Famciclovir and Valaciclovir Differ in the Prevention of Herpes Simplex Virus Type 1 Latency in Mice: a Quantitative Study""^ Persistence of Infectious Herpes Simplex Virus Type 2 in the Nervous System in Mice after Antiviral Chemotherapy""^ Observation May Indicate A Possible Clinical Effect On Latency""^ Thackray AM, Field HJ. (1996). "Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latency". J. Infect. Dis. 173 (2): 291–299. PMID 8568288.
The major drugs developed to work against herpes simplex virus (HSV) are antiviral agents called nucleosides and nucleotide analogues, which block viral reproduction. They include acyclovir (Zovirax), valacyclovir (Valtrex), famciclovir (Famvir). Read moreSmithKline Famvir(R) (famciclovir) has gained expanded indication for the treatment
Even more about Famvir
Famvir
Single-Day FAMVIR is the first and only oral antiviral proven to stop or shorten a genital herpes outbreak with just a single day of treatment.
About Single-Day FAMVIR
Single-Day FAMVIR is the first and only medication that can stop or shorten a recurrent genital herpes outbreak with just a single day of treatment.
Famciclovir - About FAMVIR
On our site you have search description of pills ... Famvir® (famciclovir) contains famciclovir, an orally administered prodrug of the antiviral agent penciclovir.
Famvir
famvir ФАМВИР. Противовирусный препарат. После приема внутрь фамцикловир быстро превращается в ...
ФАМВИР - FAMVIR - FAMVIR - Противовирусный ...
Микро-Форекс дилинговый центр с центовыми счетами ... famvir for occular herpes не состоит ни в каких группах
Comment:
