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Differin

AdapaleneSystematic (IUPAC) name6- naphthalene-2-carboxylic acidIdentifiersCAS number106685-40-9ATC codeD10AD03PubChem60164DrugBankAPRD00780Chemical dataFormulaC28H28O3 Mol. mass412.52 g/molPharmacokinetic dataBioavailabilityVery lowMetabolism ?Half life ?ExcretionBiliaryTherapeutic considerationsPregnancy cat.CLegal statusPOM(UK) ℞-only(US)RoutesTopicalAdapalene is a third-generation topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India.// IndicationsAdapalene is indicated for the topical treatment of acne vulgaris. HistoryAdapalene was approved in 1996 by the U.S. Food and Drug Administration for use in the treatment of acne. DosageAdapalene is applied once daily, after washing and before retiring. In some circumstances, when a patient complains of skin irritation, this may be decreased to once every other day until the irritation ceases. Available FormsIn the United States, adapalene is available under the brand name Differin in three different preparations: 0.1% cream, 0.1% gel, and 0.3% gel.In Europe, only the 0.1% Cream and 0.1% Gel are available. In Pakistan, adapalene is available under the brand name Clear currently only in 0.1%cream formulation by Saffron Pharmaceuticals Pharmacology Drug interactionsAdapalene has been shown to enhance the efficacy of topical clindamycin, although adverse effects are also increased. Application of adapalene gel to the skin 3–5 minutes before application of clindamycin enhances penetration of clindamycin into the skin, which may enhance the overall efficacy of the treatment as compared to clindamycin alone.Unlike tretinoin (Retin-A), adapalene has also been shown to retain its efficacy when applied at the same time as benzoyl peroxide due to its more stable chemical structure. PharmacodynamicsAdapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. It has both exfoliating and anti-inflammatory effects. The exact mode of action of adapalene is unknown. PharmacokineticsAdapalene is applied topically to the skin, and its absorption into the blood through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.

Food and Drug Administration approved Differin Gel for the treatment of acne.Acne is a common problem in children and teens and treatments include benzoyl peroxide, benzamycin, retin a, differin, tazorac and minocin.Differin (Adapalene) is a retinoidGalderma said Wednesday the U.acne cream differin - Most people who suffer from acne go out and spend good money on common over-the-counter acne treatment products.There are many products out there that claim to get rid of acne fast, but which ones work? Accutane, Differin Gel, Retin-A, Acne-n-Pimple Cream?Accutane (Isotretinoin), an extremely powerful and potent acne-controlling medicine, is used in the treatment of moderate to severe acne that has failed other therapy.S. It can only be obtained with a prescription from your doctor.Adapalene, also known as Differin is a cream or gel used for the treatment of acne.. The truth is, most of these products are full of chemicals that can actually slow down the healing

Even more about Differin

Differin

A medical prescription retinoid chemical molecule for the treatment of acne, that claims to be as effective as tretinoin 0.025%, but with low cutaneous irritation.

Acne Treatment Products: Differin

HOW TO USE DIFFERIN® PRODUCTS Step 1: Wash Right before bedtime, gently cleanse the entire face with a mild non-soap cleanser. Rinse with warm water.

Differin.com - About Differin - How To Use Differin

SUBMIT YOUR STORY Submit your story and share your success with others. In 500 words or less, tell us how Differin ® has positively improved your life.

Differin.com

ディフェリン（一般名：アダパレン）公式サイト。ガルデルマ株式会社では、医療従事者の方々と使用される患者さまを対象に、適正 ...

differin.jp　外用尋常性ざ瘡治療薬：ディフェリン ...

differin ДИФФЕРИН. Адапален представляет новое поколение синтетических ретиноидов и является ...

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