Cyklokapron
08 »
Cyklokapron
Tranexamic acidSystematic (IUPAC) name4-(aminomethyl)cyclohexane-1-carboxylic acidIdentifiersCAS number1197-18-8ATC codeB02AA02PubChem5526DrugBankAPRD01270Chemical dataFormulaC8H15NO2 Mol. mass157.21 g/molPharmacokinetic dataBioavailability34%Metabolism ?Half life3.1 hExcretion ?Therapeutic considerationsPregnancy cat.BLegal statusRoutesInjection and oralTranexamic acid (commonly marketed as Cyklokapron in the U.S. and as Transamin in Asia) is often prescribed for excessive bleeding. It is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin. Fibrin is the basic framework for the formation of a blood clot in hemostasis. It has roughly 8 times the antifibrinolytic activity of an older analogue, ε-aminoacaproic acid.// Therapeutic uses Menstrual bleedingTranexamic acid (cyklokapron, transamin) is a synthetic derivative of the amino acid lysine. It exerts its antifibrinolytic effect through the reversible blockade of lysine binding sites on plasminogen molecules. It inhibits endometrial plasminogen activator and thus prevents fibrinolysis and the breakdown of clot. Side effects are uncommon. While prolonged treatment may heighten the risk of an increased thrombotic tendency, such as deep vein thrombosis, large scale studies reveal that the incidence of thrombosis in women treated by tranexamic acid is no different from the spontaneous incidence of thrombosis in women. Tranexamic acid is used as firstline nonhormonal treatment of dysfunctional uterine bleeding, and heavy bleeding associated with uterine fibroids. A recent study showed that patients treated with tranexamic acid are more likely to develop thrombosis and necrosis in their fibroids, and may result in pain and fever. Moreover, the histological appearance of the necrosis in women treated by tranexamic acid is no different from the spontaneous incidence of thrombosis in women. ObstetricsTransexamic acid is used post-delivery to reduce bleeding, often along with syntocinon/oxytocin and fundal massage. HemophiliaTranexamic acid is also useful in the treatment of bleeding as a second line treatment next to factor VIII in patients (i.e. Tooth extraction in patients.) AngioedemaIn acquired types I and II and non-histaminergic angioedema, antifibrinolytics such as tranexamic acid or aminocaproic acid may be effective. Cardiac surgeryTranexamic acid is used in cardiac surgery, e.g. coronary artery bypass surgery, to prevent excessive blood loss. Orthopedic SurgeryTranexamic acid is used in orthopedic surgery to reduce bloodloss. It is of proven value in clearing the field of surgery and reducing pre and postoperative blood loss. Drain and number of transfusion is reduced. However the hidden blood loss is not reduced. Still it is becoming an important tool in the anaesthetist's arsenal. It is commonly used in joint replacement surgery. DentistryTranexamic acid is used in dentistry in the form of a mouth rinse after extractions or surgery in patients with prolonged bleeding time e.g. from acquired or inherited disorders.
Missing search query
Even more about Cyklokapron
Cyklokapron
Просмотр профиля atarax-kw4 ... Новости: Уважаемые посетители! Для вашего удобства мы открыли для вас ...
Просмотр профиля atarax-kw4
Learn about the prescription medication Cyklokapron (Tranexamic Acid), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.
Cyklokapron (Tranexamic Acid) Drug Information: Uses, Side Effects ...
Российские каналы. 03.12.2008 12:04:45 Телепрограмма ... Azulfidine No Rr Azulfidine No Prescription Azulfidine Dosage Azulfidine C.O.D Purchase Cyklokapron ...
Press.WebFile.ru » Изучающим английский
Российские каналы. 12.12.2008 12:08:41 Телепрограмма ... Azulfidine No Rr Azulfidine No Prescription Azulfidine Dosage Azulfidine C.O.D Purchase Cyklokapron ...
Press.WebFile.ru » Анекдоты и юмор от WebFile.ru ...
Vad är Cyklokapron? Cyklokapron är ett läkemedel som minskar blödningar. Läkemedlet tillhör läkemedelsgruppen hemostatika och det verksamma ämnet är tranexamsyra.
Comment: