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SotalolSystematic (IUPAC) nameN-{4-phenyl}methanesulfonamideIdentifiersCAS number3930-20-9ATC codeC07AA07PubChem5253DrugBankDB00489Chemical dataFormulaC12H20N2O3S Mol. mass272.3624 g/molPharmacokinetic dataBioavailability>95%MetabolismNot metabolisedHalf life12 hoursExcretionRenalLactic (In lactating females)Therapeutic considerationsPregnancy cat.B(US)Legal status℞ Prescription onlyRoutesoralSotalol (trade names Betapace and Betapace AF, Berlex Laboratories, Sotalex and Sotacor, Bristol-Myers Squibb) is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to treat hypertension in some individuals.// PharmacologyIt falls into the class III antiarrhythmic agents because it inhibits the potassium ion channels in the heart. It is also a beta blocker because of its action on the β-adrenergic receptors in the heart.By blocking the potassium channels, sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity.It also slows atrioventricular (AV) nodal conduction (beta-blocking effect).Sotalol is a racemic mix of D and L enantiomers. The L isomer is a beta blocker.Sotalol is not selected for its beta-blocking ability, but rather for its Class III (potassium blocking) properties. IndicationsSotalol is used to treat ventricular tachycardias as well as atrial fibrillation. Betapace AF is specifically labeled for atrial fibrillation.Some evidence suggests that sotalol should be avoided in the setting of decreased ejection fraction due to an increased risk of death.It has also been suggested that it be used in the prevention of atrial fibrillation.
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